by Maudh Elyamni
Introduction:
Reflecting on my recent summer experience, I am filled with a sense of accomplishment and a renewed commitment to my medical career aspirations. This summer, I had the privilege of continuing my research at the Foster Lab, a cardiology lab at Johns Hopkins University. The motivation to pursue research in cardiology stems from a profound personal loss. Both of my grandfathers passed away from heart failure at an early age, an experience that left an indelible mark on me. Witnessing two pivotal figures in my life depart this life due to this condition instilled in me a vow to help others in similar situations and to find ways to prevent such losses. This personal mission guided me to the Foster Lab, where I could contribute to research that might one day prevent heart failure and give others the precious time I lost with my grandfathers.
Key Experiences:
During my research, we investigated all-trans retinoic acid (ATRA), an active metabolite of vitamin A. ATRA plays crucial roles in cell proliferation, differentiation, and apoptosis, and it is a master regulator of gene expression within the cardiac system. Our research aimed to address the altered retinoid metabolism in heart failure, a condition affecting over 6.5 million Americans. Heart failure is characterized by a steep drop in ATRA levels, contributing to the mortality of millions annually. Preliminary research has shown that treatment with ATRA can prevent experimental heart failure by restoring cardiac ATRA levels, mitigating cardiac hypertrophy, preventing pulmonary edema, and preserving cardiac function. However, the challenge lies in the limited half-life of ATRA within the circulatory system, which makes sustained treatment in humans unfeasible. To overcome this, our research explored targeting enzymes related to the metabolism of cardiac retinoids as a potential solution for stabilizing ATRA levels in the heart. Myspecific project within the grant involved working with CRBP-/- mice, a strain thatreplicates decreased ATRA levels within the cardiac system and exhibits diastolic dysfunction. I focused on examining the impaired myofibril relaxation kinetics of these mice, aiming to uncover insights that could lead to new therapeutic strategies.
Skills and Knowledge Gained:
Throughout this internship, I not only gained technical skills in laboratory research but also developed a range of soft skills. I learned the importance of effective communication, especially when presenting complex research findings to both scientific and non-scientific audiences. Collaboration was another key skill I honed, as I worked alongside a diverse team of researchers, each bringing unique perspectives and expertise. This experience expanded the value of teamwork in achieving common goals and overcoming challenges. Impact of OKRs One of the most impactful aspects of my internship was the implementation of Objectives and Key Results (OKRs). Setting clear objectives and measurable key results provided a structured framework that guided my research efforts. It allowed me to focus on specific goals and track my progress systematically. It also helped in develop a consistent mindset which has positively improved my time management skills and helped reduce stress levels. The structured approach to balancing various aspects of life has led to improved research performance and a deeper connection with my faith. Regular relaxation periods have been crucial in preventing burnout and maintaining overall well-being.
Lessons Learned:
The lessons I learned during my internship extend beyond technical knowledge. Professionally, I gained insights into the dynamics of a research environment, understanding the importance of resilience and adaptability in the face of setbacks. I learned the significance of pursuing a careeraligned with one’s values and passions. This experience reinforced my commitment to cardiology research and my desire to make a meaningful impact in the field of medicine.
Future Applications:
My internship at the Foster Lab was a transformative experience that not only advanced my research skills but also deepened my commitment to my career goal of becoming a cardiac surgeon. The personal motivation driving my work, coupled with the invaluable experiences and lessons learned, has set a clear path for my future endeavors in cardiology research. I am excited to continue this journey, driven by the hope of making a difference in the lives of those affected by heart failure.
